1-Testosterone is a revolution in itself for the supplement industry, and with it we have entered the final leg to making supplements equally effective to steroids. Let's not kid ourselves here, some may wish to deny it, but 1-Test is an actual steroid. It's legal under the same act as prohormones, that indicates a steroidal nutrient can be sold legally if it is A) naturally occurring and B) not previously been pursued as a pharmaceutical.
The story started with the constant improvements in the area of prohormones, a weak form of steroids that needed to convert to an active form by way of (limited) bodily enzymes to an active substance such as nandrolone, testosterone, boldenone or DHT. All of them are very effective, but illegal hormones. Patrick Arnold, owner of Ergopharm and no doubt one of the prime movers in the prohormone industry, introduced a new prohormone some time back which he called 1AD. The active substance it converted to was a hormone most had never heard about, and he called it 1-testosterone. An aptly chosen name, since its basically similar to testosterone except instead of a 4,5-double bond, it has a 1,2-double bond. But the name has caused some confusion and perhaps kept a few people from seeing what the substance really was.
The absence of a 4,5-double bond and its replacement with 2 hydrogen atoms is something that occurs naturally in the body by way of an enzyme called 5-alpha-reductase. This is the same enzyme that makes DHT (Dihydro-testosterone) from testosterone. The resulting hormone is in all cases incapable of forming estrogen, allowing it to give a user smaller but much leaner gains, and add a look of hardness to the muscle for people with a relatively low body-fat. In most cases (nandrolone to dihydronandrolone being the exception) the new hormone is more androgenic. To sum up, it has reduced estrogenic and increased androgenic activity. This allows for increases in strength and aggression, reduction of body-fat, and a leaner look to the physique. If we replace the dihydro structure with a 4,5-double bond, then we would see that 1-testosterone is in fact a 5-alpha-reduced version of the hormone boldenone, a testosterone analog with an added 1,2-double bond that is characterized as being much milder than testosterone, both estrogenically and androgenically. Which would make 1-testosterone a non-aromatizing hormone, that is androgenically milder than DHT (less aggressive on hair loss and acne), but due to its altered structure is also much more active than DHT, which is readily deactivated. So Dihydro-boldenone would have been, at least from a structural viewpoint, a much better description.
TESTOREX MD WHOLESALE
In explaining what it does or how it works, some misconception has found its way into the reasoning. Again Patrick Arnold, who first likened its action to that of the steroid trenbolone (19-Nor-androsta-4,9,11-trien-3-one) lay at the base of these misconceptions. It lead most to believe we were dealing with an entirely new steroid. Fact of the matter is that 1-testosterone has been studied to a great extent and that perhaps the choice not to use it medically, at least in its original form, had other reasons. Such as for example its irritative properties. But 1-testosterone was most definitely used, albeit with one alteration : the attachment of a 1-methyl group. This alteration made it, according to the powers that be, an entirely different drug. But really this alteration has only one major impact : making it orally active. The drug in question is methenolone (primobolan). So one could, at least in terms of action, consider 1-testosterone a weak form of primobolan. Due to its lack of oral activity it is only delivered in the blood at around 14% as opposed to the much higher percentage obtained with a 1-methylation. If you know that primobolan is generally taken in 100-150 mg doses daily, then it won't surprise you that oral doses of 1-test are in the neighbourhood of at least 300 mg and probably should be higher.
So reasonably what one can expect from the use of 1-testosterone is moderate to good gains, which can probably be enhanced with the addition of an aromatizing prohormone. Usually the product will impart a harder, denser, perhaps even leaner physique on its user while never disappointing the gains it provides. Since, at least legally, it's the most potent thing for muscle growth apart from food. The user should be aware however that this is a steroid, which can never be used for more than 6-8 weeks on end, without an equally long or longer period off, because it will suppress natural testosterone secretion in the body. It's also advised that you have a good grasp of nutrition prior to using any product of this kind. This is not only imperative in achieving the maximum in terms of size, but also in keeping that size during the post-cycle period of depressed natural testosterone levels.
For all intents and purposes, 1-testosterone is a breakthrough in legal supplementation, a gateway to a new era. And already the work has progressed at an amazing pace to make 1-test as available as its analog, primobolan, in order to create a genuine legal steroid with the potency of an illegal steroid. Higher Power, Avant Labs, and Molecular Nutrition are three companies that have already made drastic steps towards achieving that. This is the supplement of the future!
Testosterone is a vital sex hormone that plays an important role in puberty. But contrary to what some people believe, testosterone isn’t exclusively a male hormone. Women produce small amounts of it in their bodies as well. In men, testosterone is produced in the testes, the reproductive glands that also produce sperm. The amount of testosterone produced in the testes is regulated by the hypothalamus and the pituitary gland.
What is a hormone?
Hormones, such as testosterone, are powerful chemicals that help keep our bodies working normally. The term hormone is derived from the Greek word, hormo, which means to set in motion. And that’s precisely what hormones do. They stimulate, regulate, and control the function of various tissues and organs. Made by specialized groups of cells within structures called glands, hormones are involved in almost every biological process, including sexual reproduction, growth, metabolism, and immune function. These glands, including the pituitary, thyroid, adrenals, ovaries and testes, release various hormones into the body as needed.
Do testosterone levels diminish with age? Does “male menopause occur?”
There is scant evidence that “male menopause,” a condition supposedly caused by diminishing testosterone levels in aging men, exists. As men age, their testes often produce somewhat less testosterone than they did during adolescence and early adulthood, when production of this hormone peaks. But it is important to keep in mind that the range of normal testosterone production is large. Many older men have testosterone levels within the normal range of healthy younger men. Others have levels well below this range. However, the likelihood that a man will ever experience a major shut down of hormone production, similar to a woman's menopause, is remote.
In fact, many of the changes that take place in older men often are incorrectly blamed on decreasing testosterone levels. Some men who have erectile difficulty (impotence), for instance, may be tempted to blame this problem on lowered testosterone. However, in many cases, erectile difficulties are due to circulatory problems, not low testosterone.
Who might benefit from testosterone therapy?
Testosterone therapy remains a scientifically unproven method for preventing or relieving any physical or psychological changes that men with normal testosterone levels may experience as they get older. Except for a relatively few younger and older men with extreme deficiencies, testosterone treatment is not deemed appropriate for most men at this time. For the few men whose bodies make very little or no testosterone—for example, men whose pituitary glands have been destroyed by infections or tumors, or whose testes have been damaged—supplements in the form of patches, injections, or topical gel may offer substantial benefit. Supplements may help a man with exceptionally low testosterone levels maintain strong muscles and bones and increase sex drive.
However, more research is needed to determine what, if any, effects testosterone replacement may have in healthy older men without these extreme deficiencies. For now, the risks and benefits of testosterone therapy for most men who do not have extreme deficiencies of the hormone are unknown, and there is insufficient evidence for making well-informed decisions on whether this therapy is suitable in these individuals.
What are some of the risks of using testosterone therapy?
Investigators are concerned about the long-term harmful effects that supplemental testosterone might have on the aging body. It is not yet known, for instance, if testosterone supplements increase the risk of prostate cancer, the second leading cause of cancer death among men. In addition to potentially promoting new prostate cancers, testosterone also may promote the growth of those that have already developed. Studies also suggest that supplementation might trigger excessive red blood cell production in some men. This side effect might thicken blood and increase a man's risk of stroke.
I know someone who uses testosterone therapy and he says he feels stronger and more “alive” than he has in years. Is there any scientific evidence to support this claim?
Although some older men who have tried these supplements report feeling "more energetic" or "younger,” testosterone supplementation remains a scientifically unproven method for preventing or relieving any physical and psychological changes that men with normal testosterone levels may experience as they get older. Until more scientifically rigorous studies are conducted, the question of whether the benefits of testosterone replacement outweigh any of its potential negative effects will remain unanswered.
So what is the NIA doing to find out more about the risks and benefits of testosterone therapy?
For more than a decade, the National Institute on Aging (NIA), a component of the Federal government’s National Institutes of Health, has supported and conducted studies of replenishing hormones and similar substances to find out if they may help reduce frailty and improve function in older people.
The NIA, for instance, is investigating the role of testosterone supplementation in delaying or preventing frailty. Results from preliminary studies involving small groups of men have been inconclusive, and it remains unclear to what degree supplementation of this hormone can sharpen memory or help men maintain stout muscles, sturdy bones, and robust sexual activity.
Why did the NIA and the National Cancer Institute ask the Institute of Medicine (IOM) for recommendations about testosterone therapy?
In 2002, the NIA and the NCI requested that the IOM conduct a 12-month study to:
Review and assess current knowledge about the risks and benefits of testosterone therapy in older men.
Prepare an evidence-based report and make recommendations regarding the design, safety, and ethics of clinical trials of this intervention, including whether such studies are even warranted.
This IOM Committee was conceived, in part, because of growing concerns about an increase in the number of older men apparently using testosterone replacement therapy (TRT) in the absence of adequate scientific information about its risks and benefits.
Many questions remain about the use of this hormone in late life. It is unclear, for example, whether men who are at the lower end of the normal range of testosterone production would benefit from supplementation. It was hoped that the Committee could recommend ways to conduct clinical trials of testosterone in this population.
What kinds of medical specialists served on this committee?
The Committee was comprised of prominent scientists specializing in epidemiology, endocrinology, geriatrics, urology, oncology, psychiatry and other relevant fields.
What did the IOM Committee conclude? What were its recommendations?
Until the safety and efficacy of testosterone therapy is older men is established, the Committee said that—outside of clinical trials—supplements of this hormone are only appropriate for indications approved by the FDA (the primary indication is hypogonadism in men who make little or no testosterone). Testosterone therapy, the Committee concluded, is inappropriate for widespread, generalized use to prevent possible age-related diseases or for enhancing strength or mood in otherwise healthy older men.
Specifically, the Committee made five major recommendations:
Conduct clinical trials in older men with low testosterone levels. These trials should be designed to assess if testosterone therapy is an effective treatment in these individuals. Establish a clear benefit before assessing long-term risks.
Begin with short-term, randomized, double-blind placebo-controlled efficacy trials in symptomatic older men with low testosterone levels to determine the potential risks and benefits. The participants should be 65 and older and have testosterone levels below the physiologic levels of young adult men. Results should be measured in four areas: weakness/frailty/disability; sexual dysfunction; cognitive dysfunction; and well-being/quality of life.
Conduct longer term studies if short-term efficacy is established. Studies to determine long-term risks and benefits should be conducted only if clinically significant benefit is established in the initial trials.
Ensure the safety of participants. The Committee recommended a system for minimizing risk and protecting participants in clinical trials of testosterone therapy.
Conduct further research. In addition to the recommendation regarding clinical trials, the Committee also suggested additional research, particularly regarding age-related changes in testosterone levels.
